Curcumin, a naturally occurring polyphenolic compound, is known to have a wide range of therapeutic and pharmacological properties. Although it is a very promising compound, its poor water solubility and fast degradation profile reduces its bioavailability to a large extent. Over a period of time, a lot of effort has been gone into the improvement of the bioavailability of native Curcumin, but it is only recently that the application of the field of nanotherapeutics has significantly improved its therapeutic efficacy.
The three major diphenolic, hydrophobic orange coloured compounds derived from the rhizome of Curcuma longa Linn. (turmeric) of the Zingiberaceae family, namely diferuloylmethane, demethoxycurcumin and bisdemethoxycurcumin have exhibited pharmacological efficacies both in preclinical and clinical studies through their anti-inflammatory, anti-microbial, anti-cancer and anti-Alzheimer properties. Furthermore, these curcuminoids also showed hepatoprotective, nephroprotective, neuroprotective, cardioprotective, hypoglycaemic activities. Researchers also observed the antioxidant properties of these novel compounds in a significant level. Therefore, all the curcuminoids were considered as an important bioactive molecules in the natural product and herbal industry.
Despite being a robust pharmacologically active agent, all the three curcuminoids exhibited very poor solubility in water and therefore the systemic bioavailability was also very low, leading to the very poor absorption, slow metabolism and systemic elimination after oral administration. Consequently, its therapeutic action and benefits also diminished significantly.
Improvement of bioavailability, curtailing the deterioration of Curcumin during its metabolism, enhancement of its delivery capacity into the tumor cells and increasing the systemic elimination time were the important purposes that led to the formulation of nanoparticles of curcumin. The nanoparticles could easily deliver the formulated curcumin into the target site. Nanocurcumin being water-soluble, showed more stability, bioavailability and curative and therapeutic action thereof.
Nanocurcumin® is a registered product of Biotex Life Solution Pvt Ltd, Hyderabad, India. This is formulated with Curcumin and a drug delivery system by a proprietary process. Nanocucumin® is a fully water-soluble preparation (Fig.1.). The intensity of Size Distribution of Nanocurcumin® is 10nm (particle diameter) (Fig:2).
The Particle size plays a very important role in the drug delivery system, mainly in the mode of action of drug including the interaction of particles with a biological system, its distribution in tissue, accumulation, attachment etc – which are all depending upon the size of particle.
The diameter of Nanocurcumin® being 10nm, the rate of absorption and permeation is higher, which finally led to the enhancement of its bio-distribution and higher circulation, furthermore increasing its bioavailability in great manifold.